SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth

Sirtuins participate in sensing nutrient availability and directing metabolic activity to match energy needs with energy production and consumption. However, the pivotal targets for sirtuins in cancer are mainly unknown. In this study, we identify the M2 isoform of pyruvate kinase (PKM2) as a critic...

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Pubblicato in:Cancer Res
Autori principali: Park, Seong-Hoon, Ozden, Ozkan, Liu, Guoxiang, Song, Ha Yong, Zhu, Yueming, Yan, Yufan, Zou, Xianghui, Kang, Hong-Jun, Jiang, Haiyan, Principe, Daniel R., Cha, Yong-Il, Roh, Meejeon, Vassilopoulos, Athanassios, Gius, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930699/
https://ncbi.nlm.nih.gov/pubmed/27197174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2498
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