SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity

Acetaminophen/paracetamol-induced liver failure—which is induced by the binding of reactive metabolites to mitochondrial proteins and their disruption—is exacerbated by fasting. As fasting promotes SIRT3-mediated mitochondrial-protein deacetylation and acetaminophen metabolites bind to lysine residu...

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Detalhes bibliográficos
Main Authors: Lu, Zhongping, Bourdi, Mohammed, Li, Jian H, Aponte, Angel M, Chen, Yong, Lombard, David B, Gucek, Marjan, Pohl, Lance R, Sack, Michael N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147261/
https://ncbi.nlm.nih.gov/pubmed/21720390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.121
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