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Mispairing C57BL/6 Substrains of Genetically Engineered Mice and Wild-Type Controls Can Lead to Confounding Results as it did in Studies of JNK2 in Acetaminophen and Concanavalin A Liver Injury

[Image: see text] C57BL/6 mice are widely used in biomedical research for the background of genetically engineered mice (GEM) and wild-type controls with the belief that the genetic background of GEM and control mice differ significantly by only one or more altered gene. This principle, however, doe...

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Bibliografiske detaljer
Main Authors: Bourdi, Mohammed, Davies, John S., Pohl, Lance R.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157912/
https://ncbi.nlm.nih.gov/pubmed/21557537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200143x
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