Prolonged Fasting Identifies Heat Shock Protein 10 as a Sirtuin 3 Substrate: ELUCIDATING A NEW MECHANISM LINKING MITOCHONDRIAL PROTEIN ACETYLATION TO FATTY ACID OXIDATION ENZYME FOLDING AND FUNCTION

Although Sirtuin 3 (SIRT3), a mitochondrially enriched deacetylase and activator of fat oxidation, is down-regulated in response to high fat feeding, the rate of fatty acid oxidation and mitochondrial protein acetylation are invariably enhanced in this dietary milieu. These paradoxical data implicat...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lu, Zhongping, Chen, Yong, Aponte, Angel M., Battaglia, Valentina, Gucek, Marjan, Sack, Michael N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303695/
https://ncbi.nlm.nih.gov/pubmed/25505263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.606228
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