Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Abstract Despite significant therapeutic advances, cumulative DOX‐induced cardiotoxicity (DIC) events remain unacceptably high. Recent evidence has underscored the critical role of impaired glycolytic metabolism in cardiovascular damage. Neuraminidase 1 (NEU1), a member of the neuraminidase family,...

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Bibliografische gegevens

Hoofdauteurs:	Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Wiley 2025-07-01
Reeks:	Advanced Science
Onderwerpen:	cardiotoxicity doxorubicin glycolysis metabolic homeostasis neuraminidase 1
Online toegang:	https://doi.org/10.1002/advs.202414504
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