SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2

BACKGROUND: Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD(+)-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we investigated additional mechanisms that might play a role in aggravating hepatic steatosis in Sirt3...

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Vydáno v:Cell Commun Signal
Hlavní autoři: Barroso, Emma, Rodríguez-Rodríguez, Rosalía, Zarei, Mohammad, Pizarro-Degado, Javier, Planavila, Anna, Palomer, Xavier, Villarroya, Francesc, Vázquez-Carrera, Manuel
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488148/
https://ncbi.nlm.nih.gov/pubmed/32912335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00640-8
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