Structure-Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells

Multidrug-resistant Gram-negative bacteria are a serious global threat to human health. Polymyxins are increasingly used in patients as a last-line therapy to treat infections caused by these life-threatening ‘superbugs’. Unfortunately, polymyxin-induced nephrotoxicity is the major dose-limiting fac...

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Publicado en:ACS Infect Dis
Main Authors: Jiang, Xukai, Zhang, Shuo, Azad, Mohammad A. K., Roberts, Kade D., Wan, Lin, Gong, Bin, Yang, Kai, Yuan, Bing, Uddin, Hemayet, Li, Jingliang, Thompson, Philip E., Velkov, Tony, Fu, Jing, Wang, Lushan, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485602/
https://ncbi.nlm.nih.gov/pubmed/32619094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00190
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