Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers

Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity and accelerated tumor evolution(1–3), but its frequency and clinical impact are unclear. Here we show, using computational analysis of whole-genome sequencing data from 3,212 cancer patients, that ecDNA amplificat...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Kim, Hoon, Nguyen, Nam-Phuong, Turner, Kristen, Wu, Sihan, Gujar, Amit D., Luebeck, Jens, Liu, Jihe, Deshpande, Viraj, Rajkumar, Utkrisht, Namburi, Sandeep, Amin, Samirkumar B., Yi, Eunhee, Menghi, Francesca, Schulte, Johannes H., Henssen, Anton G., Chang, Howard Y., Beck, Christine, Mischel, Paul S., Bafna, Vineet, Verhaak, Roel G.W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484012/
https://ncbi.nlm.nih.gov/pubmed/32807987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0678-2
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