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Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
Focal oncogene amplification and rearrangements drive tumor growth and evolution in multiple cancer types. We present AmpliconArchitect (AA), a tool to reconstruct the fine structure of focally amplified regions using whole genome sequencing (WGS) and validate it extensively on multiple simulated an...
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| 發表在: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6344493/ https://ncbi.nlm.nih.gov/pubmed/30674876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08200-y |
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