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ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer

The integration of viral sequences into the host genome is an important driver of tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular carcinoma. We present ViFi, a computational method that combines phylogenetic methods with reference-based read mapping to detect...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Nguyen, Nam-phuong D, Deshpande, Viraj, Luebeck, Jens, Mischel, Paul S, Bafna, Vineet
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283451/
https://ncbi.nlm.nih.gov/pubmed/29579309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky180
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