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Extrachromosomal Oncogene Amplification in Tumor Pathogenesis and Evolution.
Recent reports have demonstrated that oncogene amplification on extrachromosomal DNA (ecDNA) is a frequent event in cancer, providing new momentum to explore a phenomenon first discovered several decades ago. The direct consequence of ecDNA gains in these cases is an increase in DNA copy number of t...
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| 發表在: | Nat Rev Cancer |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7168519/ https://ncbi.nlm.nih.gov/pubmed/30872802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41568-019-0128-6 |
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