Functional enhancers shape extrachromosomal oncogene amplifications

Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant co-amplification of non-coding DNA beyond the boundaries of amplified oncogenes across five cancer types. In glioblastoma, EGFR is preferentially co-ampli...

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: Morton, Andrew R., Dogan-Artun, Nergiz, Faber, Zachary J., MacLeod, Graham, Bartels, Cynthia F., Piazza, Megan S., Allan, Kevin C., Mack, Stephen C., Wang, Xiuxing, Gimple, Ryan C., Wu, Qiulian, Rubin, Brian P., Shetty, Shashirekha, Angers, Stephane, Dirks, Peter B., Sallari, Richard C., Lupien, Mathieu, Rich, Jeremy N., Scacheri, Peter C.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241652/
https://ncbi.nlm.nih.gov/pubmed/31761532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.10.039
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