FSMP-08. TARGETING PYRIMIDINE SYNTHESIS ACCENTUATES MOLECULAR THERAPY RESPONSE IN GLIOBLASTOMA STEM CELLS

Glioblastoma stem cells (GSCs) reprogram glucose metabolism by hijacking high-affinity glucose uptake to survive in a nutritionally dynamic microenvironment. Here, we trace metabolic aberrations in GSCs to link core genetic mutations in glioblastoma to dependency on de novo pyrimidine synthesis. Tar...

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Dettagli Bibliografici
Pubblicato in:Neurooncol Adv
Autori principali: Yang, Kailin, Wang, Xiuxing, Wu, Qiulian, Kim, Leo, Morton, Andrew, Gimple, Ryan, Prager, Briana, Tao, Weiwei, Qiu, Zhixin, Zhao, Linjie, Agnihotri, Sameer, Mischel, Paul, Mack, Stephen, Bao, Shideng, Rich, Jeremy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
Soggetti:
Supplement Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992239/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab024.072
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