Exploring the landscape of focal amplifications in cancer using AmpliconArchitect

Focal oncogene amplification and rearrangements drive tumor growth and evolution in multiple cancer types. We present AmpliconArchitect (AA), a tool to reconstruct the fine structure of focally amplified regions using whole genome sequencing (WGS) and validate it extensively on multiple simulated an...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Deshpande, Viraj, Luebeck, Jens, Nguyen, Nam-Phuong D., Bakhtiari, Mehrdad, Turner, Kristen M., Schwab, Richard, Carter, Hannah, Mischel, Paul S., Bafna, Vineet
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344493/
https://ncbi.nlm.nih.gov/pubmed/30674876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08200-y
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