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Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy
Damaged mitochondria are selectively eliminated in a process called mitophagy. Parkin and PINK1, proteins mutated in Parkinson’s disease, amplify ubiquitin signals on damaged mitochondria with the subsequent activation of autophagic machinery. Autophagy adaptors are thought to link ubiquitinated mit...
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| 出版年: | J Cell Biol |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Rockefeller University Press
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7480101/ https://ncbi.nlm.nih.gov/pubmed/32556086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201912144 |
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