Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy

Damaged mitochondria are selectively eliminated in a process called mitophagy. Parkin and PINK1, proteins mutated in Parkinson’s disease, amplify ubiquitin signals on damaged mitochondria with the subsequent activation of autophagic machinery. Autophagy adaptors are thought to link ubiquitinated mit...

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Vydáno v:J Cell Biol
Hlavní autoři: Yamano, Koji, Kikuchi, Reika, Kojima, Waka, Hayashida, Ryota, Koyano, Fumika, Kawawaki, Junko, Shoda, Takuji, Demizu, Yosuke, Naito, Mikihiko, Tanaka, Keiji, Matsuda, Noriyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480101/
https://ncbi.nlm.nih.gov/pubmed/32556086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201912144
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