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Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety

Targeted protein degradation using small chimeric molecules, such as proteolysis-targeting chimeras (PROTACs) and specific and nongenetic inhibitors of apoptosis protein [IAP]-dependent protein erasers (SNIPERs), is a promising technology in drug discovery. We recently developed a novel class of chi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pharmaceuticals (Basel)
Prif Awduron: Shoda, Takuji, Ohoka, Nobumichi, Tsuji, Genichiro, Fujisato, Takuma, Inoue, Hideshi, Demizu, Yosuke, Naito, Mikihiko, Kurihara, Masaaki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7151680/
https://ncbi.nlm.nih.gov/pubmed/32106507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph13030034
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