Development of Agonist-Based PROTACs Targeting Liver X Receptor

Liver X receptors (LXRs) belong to the nuclear hormone receptor superfamily and function as ligand-dependent transcription factors that regulate cholesterol homeostasis, lipid homeostasis, and immune responses. LXR antagonists are promising treatments for hypercholesterolemia and diabetes. However,...

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Foilsithe in:Front Chem
Main Authors: Xu, Hanqiao, Ohoka, Nobumichi, Yokoo, Hidetomo, Nemoto, Kanako, Ohtsuki, Takashi, Matsufuji, Hiroshi, Naito, Mikihiko, Inoue, Takao, Tsuji, Genichiro, Demizu, Yosuke
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2021
Ábhair:
Chemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187946/
https://ncbi.nlm.nih.gov/pubmed/34124002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2021.674967
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