Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

BACKGROUND: In acquired aplastic anemia, the immune system destroys hematopoietic cells, leading to pancytopenia. Patients respond to immunosuppressive therapy but about 15 per cent develop myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), usually many months to years after diagnosis...

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izdano v:N Engl J Med
Main Authors: Yoshizato, Tetsuichi, Dumitriu, Bogdan, Hosokawa, Kohei, Makishima, Hideki, Yoshida, Kenichi, Townsley, Danielle, Sato-Otsubo, Aiko, Sato, Yusuke, Liu, Delong, Suzuki, Hiromichi, Wu, Colin O., Shiraishi, Yuichi, Clemente, Michael J., Kataoka, Keisuke, Shiozawa, Yusuke, Okuno, Yusuke, Chiba, Kenichi, Tanaka, Hiroko, Nagata, Yasunobu, Katagiri, Takamasa, Kon, Ayana, Sanada, Masashi, Scheinberg, Phillip, Miyano, Satoru, Maciejewski, Jaroslaw P., Nakao, Shinji, Young, Neal S., Ogawa, Seishi
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478337/
https://ncbi.nlm.nih.gov/pubmed/26132940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1414799
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