Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia

Spliceosome mutations are frequently found in myelodysplasia. Splicing alterations induced by these mutations, their precise targets, and the effect at the transcript level have not been fully elucidated. Here we report transcriptomic analyses of 265 bone marrow samples from myelodysplasia patients,...

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Vydáno v:Nat Commun
Hlavní autoři: Shiozawa, Yusuke, Malcovati, Luca, Gallì, Anna, Sato-Otsubo, Aiko, Kataoka, Keisuke, Sato, Yusuke, Watatani, Yosaku, Suzuki, Hiromichi, Yoshizato, Tetsuichi, Yoshida, Kenichi, Sanada, Masashi, Makishima, Hideki, Shiraishi, Yuichi, Chiba, Kenichi, Hellström-Lindberg, Eva, Miyano, Satoru, Ogawa, Seishi, Cazzola, Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128865/
https://ncbi.nlm.nih.gov/pubmed/30194306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06063-x
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