Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

BACKGROUND: In acquired aplastic anemia, the immune system destroys hematopoietic cells, leading to pancytopenia. Patients respond to immunosuppressive therapy but about 15 per cent develop myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), usually many months to years after diagnosis...

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Detalhes bibliográficos
Publicado no:N Engl J Med
Main Authors: Yoshizato, Tetsuichi, Dumitriu, Bogdan, Hosokawa, Kohei, Makishima, Hideki, Yoshida, Kenichi, Townsley, Danielle, Sato-Otsubo, Aiko, Sato, Yusuke, Liu, Delong, Suzuki, Hiromichi, Wu, Colin O., Shiraishi, Yuichi, Clemente, Michael J., Kataoka, Keisuke, Shiozawa, Yusuke, Okuno, Yusuke, Chiba, Kenichi, Tanaka, Hiroko, Nagata, Yasunobu, Katagiri, Takamasa, Kon, Ayana, Sanada, Masashi, Scheinberg, Phillip, Miyano, Satoru, Maciejewski, Jaroslaw P., Nakao, Shinji, Young, Neal S., Ogawa, Seishi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478337/
https://ncbi.nlm.nih.gov/pubmed/26132940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1414799
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