Telomere attrition and candidate gene mutations preceding monosomy 7 in aplastic anemia

The pathophysiology of severe aplastic anemia (SAA) is immune-mediated destruction of hematopoietic stem and progenitor cells (HSPCs). Most patients respond to immunosuppressive therapies, but a minority transform to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), frequently associa...

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Publicado en:Blood
Autores principales: Dumitriu, Bogdan, Feng, Xingmin, Townsley, Danielle M., Ueda, Yasutaka, Yoshizato, Tetsuichi, Calado, Rodrigo T., Yang, Yanqin, Wakabayashi, Yoshiyuki, Kajigaya, Sachiko, Ogawa, Seishi, Zhu, Jun, Young, Neal S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Red Cells, Iron, and Erythropoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304114/
https://ncbi.nlm.nih.gov/pubmed/25406353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-607572
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