Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations

SF3B1, SRSF2, and U2AF1 are the most frequently mutated splicing factor genes in the myelodysplastic syndromes (MDS). We have performed a comprehensive and systematic analysis to determine the effect of these commonly mutated splicing factors on pre-mRNA splicing in the bone marrow stem/progenitor c...

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Bibliografski detalji
Izdano u:Blood
Glavni autori: Pellagatti, Andrea, Armstrong, Richard N., Steeples, Violetta, Sharma, Eshita, Repapi, Emmanouela, Singh, Shalini, Sanchi, Andrea, Radujkovic, Aleksandar, Horn, Patrick, Dolatshad, Hamid, Roy, Swagata, Broxholme, John, Lockstone, Helen, Taylor, Stephen, Giagounidis, Aristoteles, Vyas, Paresh, Schuh, Anna, Hamblin, Angela, Papaemmanuil, Elli, Killick, Sally, Malcovati, Luca, Hennrich, Marco L., Gavin, Anne-Claude, Ho, Anthony D., Luft, Thomas, Hellström-Lindberg, Eva, Cazzola, Mario, Smith, Christopher W. J., Smith, Stephen, Boultwood, Jacqueline
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2018
Teme:
Plenary Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172604/
https://ncbi.nlm.nih.gov/pubmed/29930011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-04-843771
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