Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia

Spliceosome mutations are frequently found in myelodysplasia. Splicing alterations induced by these mutations, their precise targets, and the effect at the transcript level have not been fully elucidated. Here we report transcriptomic analyses of 265 bone marrow samples from myelodysplasia patients,...

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Publicado en:Nat Commun
Autores principales: Shiozawa, Yusuke, Malcovati, Luca, Gallì, Anna, Sato-Otsubo, Aiko, Kataoka, Keisuke, Sato, Yusuke, Watatani, Yosaku, Suzuki, Hiromichi, Yoshizato, Tetsuichi, Yoshida, Kenichi, Sanada, Masashi, Makishima, Hideki, Shiraishi, Yuichi, Chiba, Kenichi, Hellström-Lindberg, Eva, Miyano, Satoru, Ogawa, Seishi, Cazzola, Mario
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128865/
https://ncbi.nlm.nih.gov/pubmed/30194306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06063-x
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