Agonist-induced formation of unproductive receptor-G(12) complexes

G proteins are activated when they associate with G protein-coupled receptors (GPCRs), often in response to agonist-mediated receptor activation. It is generally thought that agonist-induced receptor-G protein association necessarily promotes G protein activation and, conversely, that activated GPCR...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Okashah, Najeah, Wright, Shane C., Kawakami, Kouki, Mathiasen, Signe, Zhou, Joris, Lu, Sumin, Javitch, Jonathan A., Inoue, Asuka, Bouvier, Michel, Lambert, Nevin A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474645/
https://ncbi.nlm.nih.gov/pubmed/32817560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003787117
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