Homogeneous Oligomers of Pro-Apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization

BAX is a pro-apoptotic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial outer membrane. How BAX monomers assemble into a higher-order conformation, and the structural determinants essential to membrane permeabilization, remain a mechanistic...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Hauseman, Zachary J., Harvey, Edward P., Newman, Catherine E., Wales, Thomas E., Bucci, Joel C., Mintseris, Julian, Schweppe, Devin K., David, Liron, Fan, Lixin, Cohen, Daniel T., Herce, Henry D., Mourtada, Rida, Ben-Nun, Yael, Bloch, Noah B., Hansen, Scott B., Wu, Hao, Gygi, Steven P., Engen, John R., Walensky, Loren D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472837/
https://ncbi.nlm.nih.gov/pubmed/32533918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.05.029
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