The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in multiple forms of Parkinson’s disease, both idiopathic as well as familial forms linked to mutations in the LRRK2 gene. However, sensitive quantitative markers of LRRK2 activation in clinical samples remain at...

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Dades bibliogràfiques
Publicat a:Front Neurosci
Autors principals: Rideout, Hardy J., Chartier-Harlin, Marie-Christine, Fell, Matthew J., Hirst, Warren D., Huntwork-Rodriguez, Sarah, Leyns, Cheryl E. G., Mabrouk, Omar S., Taymans, Jean-Marc
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461933/
https://ncbi.nlm.nih.gov/pubmed/33013290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00865
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