Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients

Leucine-rich repeat kinase 2 (LRRK2) mutations are among the most significant genetic risk factors for developing late onset Parkinson’s disease (PD). To understand whether a therapeutic can modulate LRRK2 levels as a potential disease modifying strategy, it is important to have methods in place to...

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Bibliografiska uppgifter
I publikationen:Front Neurosci
Huvudupphovsmän: Mabrouk, Omar S., Chen, Siwei, Edwards, Amanda L., Yang, Minhua, Hirst, Warren D., Graham, Danielle L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2020
Ämnen:
Neuroscience
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7262382/
https://ncbi.nlm.nih.gov/pubmed/32523511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00526
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