The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in multiple forms of Parkinson’s disease, both idiopathic as well as familial forms linked to mutations in the LRRK2 gene. However, sensitive quantitative markers of LRRK2 activation in clinical samples remain at...

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Bibliographische Detailangaben
Veröffentlicht in:Front Neurosci
Hauptverfasser: Rideout, Hardy J., Chartier-Harlin, Marie-Christine, Fell, Matthew J., Hirst, Warren D., Huntwork-Rodriguez, Sarah, Leyns, Cheryl E. G., Mabrouk, Omar S., Taymans, Jean-Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461933/
https://ncbi.nlm.nih.gov/pubmed/33013290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00865
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