GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2

Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the most common cause of familial Parkinson's disease (PD), and sequence variants modify risk for sporadic PD. Previous studies indicate that LRRK2 interacts with microtubules (MTs) and alters MT-mediated vesicular transport processes....

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Pubblicato in:Hum Mol Genet
Autori principali: Blanca Ramírez, Marian, Ordóñez, Antonio Jesús Lara, Fdez, Elena, Madero-Pérez, Jesús, Gonnelli, Adriano, Drouyer, Matthieu, Chartier-Harlin, Marie-Christine, Taymans, Jean-Marc, Bubacco, Luigi, Greggio, Elisa, Hilfiker, Sabine
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886193/
https://ncbi.nlm.nih.gov/pubmed/28453723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx161
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