Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity

hRpn13/ADRM1 links substrate recruitment with deubiquitination at the proteasome through its proteasome- and ubiquitin-binding Pru domain and DEUBAD domain, which binds and activates deubiquitinating enzyme (DUB) UCHL5/Uch37. Here, we edit the HCT116 colorectal cancer cell line to delete part of the...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Osei-Amponsa, Vasty, Sridharan, Vinidhra, Tandon, Mayank, Evans, Christine N., Klarmann, Kimberly, Cheng, Kwong Tai, Lack, Justin, Chari, Raj, Walters, Kylie J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7459265/
https://ncbi.nlm.nih.gov/pubmed/32631902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00122-20
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