Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10

Regulated proteolysis by proteasomes involves ~800 enzymes for substrate modification with ubiquitin, including ~600 E3 ligases. We report here that E6AP/UBE3A is distinguished from other E3 ligases by having a 12 nM binding site at the proteasome contributed by substrate receptor hRpn10/PSMD4/S5a....

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Udgivet i:Nat Commun
Main Authors: Buel, Gwen R., Chen, Xiang, Chari, Raj, O’Neill, Maura J., Ebelle, Danielle L., Jenkins, Conor, Sridharan, Vinidhra, Tarasov, Sergey G., Tarasova, Nadya I., Andresson, Thorkell, Walters, Kylie J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064531/
https://ncbi.nlm.nih.gov/pubmed/32157086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15073-7
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