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An extended conformation for K48 ubiquitin chains revealed by the hRpn2:Rpn13:K48-diubiquitin structure
Rpn13/Adrm1 is recruited to the proteasome by PSMD1/Rpn2, where it serves as a substrate receptor that binds preferentially to K48-linked ubiquitin chains, an established signal for protein proteolysis. Here, we use NMR to solve the structure of hRpn13 Pru:hRpn2 (940–953):K48-diubiquitin. Surprising...
Shranjeno v:
| izdano v: | Structure |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7205571/ https://ncbi.nlm.nih.gov/pubmed/32160516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.02.007 |
| Oznake: |
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