Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

During the last few decades, the global incidence of dengue virus (DENV) has increased dramatically, and it is now endemic in more than 100 countries. To establish a productive infection in humans, DENV uses different strategies to inhibit or avoid the host innate immune system. Several DENV protein...

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Publicado no:Nat Microbiol
Main Authors: Aguirre, Sebastian, Luthra, Priya, Sanchez-Aparicio, Maria T., Maestre, Ana M., Patel, Jenish, Lamothe, Francise, Fredericks, Anthony C., Tripathi, Shashank, Zhu, Tongtong, Pintado-Silva, Jessica, Webb, Laurence G., Bernal-Rubio, Dabeiba, Solovyov, Alexander, Greenbaum, Benjamin, Simon, Viviana, Basler, Christopher F., Mulder, Lubbertus C. F., García-Sastre, Adolfo, Fernandez-Sesma, Ana
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457382/
https://ncbi.nlm.nih.gov/pubmed/28346446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmicrobiol.2017.37
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