Contribution of Double-Stranded RNA and CPSF30 Binding Domains of Influenza Virus NS1 to the Inhibition of Type I Interferon Production and Activation of Human Dendritic Cells

The influenza virus nonstructural protein 1 (NS1) inhibits innate immunity by multiple mechanisms. We previously reported that NS1 is able to inhibit the production of type I interferon (IFN) and proinflammatory cytokines in human primary dendritic cells (DCs). Here, we used recombinant viruses expr...

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Hlavní autoři: Ramos, Irene, Carnero, Elena, Bernal-Rubio, Dabeiba, Seibert, Christopher W., Westera, Liset, García-Sastre, Adolfo, Fernandez-Sesma, Ana
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571370/
https://ncbi.nlm.nih.gov/pubmed/23255794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02247-12
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