BET Inhibition-Induced GSK3β Feedback Enhances Lymphoma Vulnerability to PI3K Inhibitors

The phosphatidylinositol 3 kinase (PI3K)-glycogen synthase kinase β (GSK3β) axis plays a central role in MYC-driven lymphomagenesis, and MYC targeting with bromodomain and extraterminal protein family inhibitors (BETi) is a promising treatment strategy in lymphoma. In a high-throughput combinatorial...

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Publicado en:Cell Rep
Autores principales: Derenzini, Enrico, Mondello, Patrizia, Erazo, Tatiana, Portelinha, Ana, Liu, Yuxuan, Scallion, Mary, Asgari, Zahra, Philip, John, Hilden, Patrick, Valli, Debora, Rossi, Alessandra, Djaballah, Hakim, Ouerfelli, Ouathek, de Stanchina, Elisa, Seshan, Venkatraman E., Hendrickson, Ronald C., Younes, Anas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456333/
https://ncbi.nlm.nih.gov/pubmed/30134175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.055
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