Dual inhibition of histone deacetylases and phosphoinositide 3-kinase enhances therapeutic activity against B cell lymphoma

Phosphoinositide 3-kinase (PI3K) and Myc are known to cooperate in promoting the survival and growth of a variety of B-cell lymphomas. While currently there are no small molecule inhibitors of Myc protein, histone deacetylase (HDAC) inhibitors have been shown to reduce levels of Myc protein by suppr...

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Udgivet i:Oncotarget
Main Authors: Mondello, Patrizia, Derenzini, Enrico, Asgari, Zahra, Philip, John, Brea, Elliott J., Seshan, Venkatraman, Hendrickson, Ronald C., de Stanchina, Elisa, Scheinberg, David A., Younes, Anas
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355158/
https://ncbi.nlm.nih.gov/pubmed/28147336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14876
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