ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors

Inhibition of the extracellular signal-regulated kinases ERK1 and ERK2 (ERK1/2) offers a promising therapeutic strategy in cancers harboring activated RAS/RAF/MEK/ERK signaling pathways. Here, we describe an orally bioavailable and selective ERK1/2 inhibitor, ASN007, currently in clinical developmen...

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Detalhes bibliográficos
Publicado no:Cell Rep Med
Main Authors: Portelinha, Ana, Thompson, Scott, Smith, Roger A., Da Silva Ferreira, Mariana, Asgari, Zahra, Knezevic, Andrea, Seshan, Venkatraman, de Stanchina, Elisa, Gupta, Sandeep, Denis, Louis, Younes, Anas, Reddy, Sanjeeva
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324497/
https://ncbi.nlm.nih.gov/pubmed/34337566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100350
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