Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABA(A)) receptors

Allopregnanolone (3α5α-P), pregnanolone, and their synthetic derivatives are potent positive allosteric modulators (PAMs) of GABA(A) receptors (GABA(A)Rs) with in vivo anesthetic, anxiolytic, and anti-convulsant effects. Mutational analysis, photoaffinity labeling, and structural studies have provid...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Jayakar, Selwyn S., Chiara, David C., Zhou, Xiaojuan, Wu, Bo, Bruzik, Karol S., Miller, Keith W., Cohen, Jonathan B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7450100/
https://ncbi.nlm.nih.gov/pubmed/32540960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013452
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