Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity

BACKGROUND: Adenovirus serotype 5 (Ad5) is a commonly used viral vector for transient delivery of transgenes, primarily for vaccination against pathogen and tumor antigens. However, endemic infections with Ad5 produce virus-specific neutralizing antibodies (NAbs) that limit transgene delivery and co...

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書目詳細資料
發表在:J Immunother Cancer
Main Authors: Flickinger Jr, John C, Singh, Jagmohan, Carlson, Robert, Leong, Elinor, Baybutt, Trevor R, Barton, Joshua, Caparosa, Ellen, Pattison, Amanda, Rappaport, Jeffrey A, Roh, Jamin, Zhan, Tingting, Bashir, Babar, Waldman, Scott A, Snook, Adam E
格式: Artigo
語言:Inglês
出版: BMJ Publishing Group 2020
主題:
Clinical/Translational Cancer Immunotherapy
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443303/
https://ncbi.nlm.nih.gov/pubmed/32819976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001046
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