Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity

BACKGROUND: Adenovirus serotype 5 (Ad5) is a commonly used viral vector for transient delivery of transgenes, primarily for vaccination against pathogen and tumor antigens. However, endemic infections with Ad5 produce virus-specific neutralizing antibodies (NAbs) that limit transgene delivery and co...

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Udgivet i:J Immunother Cancer
Main Authors: Flickinger Jr, John C, Singh, Jagmohan, Carlson, Robert, Leong, Elinor, Baybutt, Trevor R, Barton, Joshua, Caparosa, Ellen, Pattison, Amanda, Rappaport, Jeffrey A, Roh, Jamin, Zhan, Tingting, Bashir, Babar, Waldman, Scott A, Snook, Adam E
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2020
Fag:
Clinical/Translational Cancer Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443303/
https://ncbi.nlm.nih.gov/pubmed/32819976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001046
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