Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity

BACKGROUND: Adenovirus serotype 5 (Ad5) is a commonly used viral vector for transient delivery of transgenes, primarily for vaccination against pathogen and tumor antigens. However, endemic infections with Ad5 produce virus-specific neutralizing antibodies (NAbs) that limit transgene delivery and co...

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Dades bibliogràfiques
Publicat a:J Immunother Cancer
Autors principals: Flickinger Jr, John C, Singh, Jagmohan, Carlson, Robert, Leong, Elinor, Baybutt, Trevor R, Barton, Joshua, Caparosa, Ellen, Pattison, Amanda, Rappaport, Jeffrey A, Roh, Jamin, Zhan, Tingting, Bashir, Babar, Waldman, Scott A, Snook, Adam E
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2020
Matèries:
Clinical/Translational Cancer Immunotherapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443303/
https://ncbi.nlm.nih.gov/pubmed/32819976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001046
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