GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity

Adoptive T-cell therapy (ACT) is an emerging paradigm in which T cells are genetically modified to target cancer-associated antigens and eradicate tumors. However, challenges treating epithelial cancers with ACT reflect antigen targets that are not tumor-specific, permitting immune damage to normal...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Autores principales: Magee, Michael S., Kraft, Crystal L., Abraham, Tara S., Baybutt, Trevor R., Marszalowicz, Glen P., Li, Peng, Waldman, Scott A., Snook, Adam E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087292/
https://ncbi.nlm.nih.gov/pubmed/27853651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1227897
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