ALKBH7 mediates necrosis via rewiring of glyoxal metabolism

Alkb homolog 7 (ALKBH7) is a mitochondrial α-ketoglutarate dioxygenase required for DNA alkylation-induced necrosis, but its function and substrates remain unclear. Herein, we show ALKBH7 regulates dialdehyde metabolism, which impacts the cardiac response to ischemia-reperfusion (IR) injury. Using a...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Kulkarni, Chaitanya A, Nadtochiy, Sergiy M, Kennedy, Leslie, Zhang, Jimmy, Chhim, Sophea, Alwaseem, Hanan, Murphy, Elizabeth, Fu, Dragony, Brookes, Paul S
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442491/
https://ncbi.nlm.nih.gov/pubmed/32795389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58573
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi