ALKBH7 mediates necrosis via rewiring of glyoxal metabolism

Alkb homolog 7 (ALKBH7) is a mitochondrial α-ketoglutarate dioxygenase required for DNA alkylation-induced necrosis, but its function and substrates remain unclear. Herein, we show ALKBH7 regulates dialdehyde metabolism, which impacts the cardiac response to ischemia-reperfusion (IR) injury. Using a...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Kulkarni, Chaitanya A, Nadtochiy, Sergiy M, Kennedy, Leslie, Zhang, Jimmy, Chhim, Sophea, Alwaseem, Hanan, Murphy, Elizabeth, Fu, Dragony, Brookes, Paul S
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442491/
https://ncbi.nlm.nih.gov/pubmed/32795389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58573
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