GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing Sarcoma

Ewing sarcoma (EWS) is the second most common and aggressive type of metastatic bone tumor in adolescents and young adults. There is unmet medical need to develop and test novel pharmacological targets and novel therapies to treat EWS. Here, we found that EWS expresses high levels of a p53 isoform,...

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Veröffentlicht in:Int J Cancer
Hauptverfasser: Charan, Manish, Dravid, Piyush, Cam, Maren, Audino, Anthony, Gross, Amy C., Arnold, Michael A., Roberts, Ryan D., Cripe, Timothy P., Pertsemlidis, Alexander, Houghton, Peter J., Cam, Hakan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7440656/
https://ncbi.nlm.nih.gov/pubmed/31621900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32743
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