ΔNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis

The tumor suppressor gene p53 and its family members p63/p73 are critical determinants of tumorigenesis. ΔNp63 is a splice variant of p63, which lacks the N-terminal transactivation domain. It is thought to antagonize p53-, p63- and p73- dependent translation, thus blocking their tumor suppressor ac...

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Bibliografiske detaljer
Main Authors: Bid, Hemant K., Roberts, Ryan D., Cam, Maren, Audino, Anthony, Kurmasheva, Raushan T., Lin, Jiayuh, Houghton, Peter J., Cam, Hakan
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950294/
https://ncbi.nlm.nih.gov/pubmed/24154873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0894
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