GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing Sarcoma

Ewing sarcoma (EWS) is the second most common and aggressive type of metastatic bone tumor in adolescents and young adults. There is unmet medical need to develop and test novel pharmacological targets and novel therapies to treat EWS. Here, we found that EWS expresses high levels of a p53 isoform,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Cancer
Prif Awduron: Charan, Manish, Dravid, Piyush, Cam, Maren, Audino, Anthony, Gross, Amy C., Arnold, Michael A., Roberts, Ryan D., Cripe, Timothy P., Pertsemlidis, Alexander, Houghton, Peter J., Cam, Hakan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7440656/
https://ncbi.nlm.nih.gov/pubmed/31621900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32743
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