GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing Sarcoma

Ewing sarcoma (EWS) is the second most common and aggressive type of metastatic bone tumor in adolescents and young adults. There is unmet medical need to develop and test novel pharmacological targets and novel therapies to treat EWS. Here, we found that EWS expresses high levels of a p53 isoform,...

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Publicado no:Int J Cancer
Main Authors: Charan, Manish, Dravid, Piyush, Cam, Maren, Audino, Anthony, Gross, Amy C., Arnold, Michael A., Roberts, Ryan D., Cripe, Timothy P., Pertsemlidis, Alexander, Houghton, Peter J., Cam, Hakan
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7440656/
https://ncbi.nlm.nih.gov/pubmed/31621900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32743
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