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Loss of Both CDKN2A and CDKN2B Allows for Centrosome Overduplication in Melanoma
Centrosomes duplicate only once in coordination with the DNA replication cycle and have an important role in segregating genetic material. In contrast, most cancer cells have centrosome aberrations, including supernumerary centrosomes, and this correlates with aneuploidy and genetic instability. The...
Shranjeno v:
| izdano v: | J Invest Dermatol |
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| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7435684/ https://ncbi.nlm.nih.gov/pubmed/32067956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.01.024 |
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